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Grant Applications Often Provide Early-Stage Funding

Startup Professionals Musings

This process costs money, which professional investors are not willing to contribute, since their interest is in scaling a proven product and business model into a growth business. Specifically, I often point to the NSF or the Small Business Innovation Research (SBIR) program for high-tech startups.

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Reinventing Life Science Startups – Evidence-based Entrepreneurship

Steve Blank

What we found is that during the class almost all of them pivoted - making substantive changes to one or more of their business model canvas components. In the real world a big pivot in life sciences far down the road of development is a very bad sign due to huge sunk costs.

SBIR 316
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Lessons for the DoD – From Ukraine and China

Steve Blank

The Ukraine conflict is demonstrating the changing character of war such that low-cost emerging commercial technology is extremely effective when deployed against a larger 20th-century industrialized force that Russia is fielding. Venture capital and startups have spent 50 years institutionalizing the rapid delivery of disruptive innovation.

Ukraine 287
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I-Corps at the NIH: Evidence-based Translational Medicine

Steve Blank

With that SBIR-Phase 1 funding the teams were trying to establish the technical merit, feasibility, and commercial potential of their technology. We’ve learned that information from 100 customers is just at the edge of having sufficient data to validate/invalidate a company’s business model hypotheses. Lessons Learned.

SBIR 266
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How to Build a Healthcare Startup

Up and Running

For example, having flexible work hours means you can hire talented candidates from different time zones, which will increase your productivity while keeping the costs down. Your health startup business plan should be a tool to guide your growth. At first, you need to focus on developing your business model and validating it.

SBIR 73
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The Apple Watch – Tipping Point Time for Healthcare

Steve Blank

Mastering the reimbursement path requires a company to have yet another group of specialists conduct expensive clinical cost outcomes studies. The other interesting observation: Unlike other medical device companies, Apple’s current Watch business model is not dependent on getting insurers to pay for the watch. The Future.

China 67
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Office of Naval Research (ONR) Goes Lean

Steve Blank

Dual-use” products reduce the cost for defense adoption of products. Prioritization : Once a list of innovation ideas has been refined by curation, it needs to be prioritized using the McKinsey Three Horizons Model. Horizon 1 ideas provide continuous innovation to a company’s existing business model and core capabilities.

Lean 220